NEW YORK (CNNMoney) -- JPMorgan Chase announced Monday that Ina Drew, the firm's chief investment officer, has left the bank after revelations of a $2 billion loss sustained over the past six weeks.

A statement issued by the company said Drew made the decision to retire, a move that was widely expected after the company disclosed the unit she managed had suffered a major loss.

The group had been making trades designed to hedge against risk, but had amassed a large position in credit-default swaps that began to sour.

Net losses, after factoring in other securities gains, are expected to exceed $800 million by the end of the second quarter. And losses could increase depending on market conditions and the bank's actions moving forward.

The unit had been expected to post a net gain of $200 million.

One of the highest paid women in the financial industry, Drew made $15.5 million in 2010. She has spent more than 30 years at JPMorgan (JPM, Fortune 500).

"Despite our recent losses in the CIO, Ina's vast contributions to our company should not be overshadowed by these events," CEO Jamie Dimon said in a statement.

Drew is in line to receive $14.7 million severance in the form of stock, $2.6 million in pension benefits and almost $10 million in deferred compensation, according to Theo Francis, a senior reporter at footnoted.com, a website that specializes in SEC filings. (Francis is married to a CNNMoney reporter)

The company's board of directors could award additional severance pay.

JPMorgan said that Matt Zames, who is currently the co-head of global fixed income in the investment bank and head of capital markets within the mortgage bank, would succeed Drew.

Zames was formerly a senior trader at Long-Term Capital Management, the failed hedge fund that placed massive bets on the trajectory of interest rates and required a $3.6 billion bailout from the Federal Reserve in 1998.

"Nobody knows about the dangers of what's happening at JPMorgan more than Matt," said James Rickards, former general counsel at Long-Term Capital Management.

"My question for management is why didn't they enlist Matt earlier to look over Ina's shoulder," said Rickards, now a senior managing director at the merchant bank Tangent Capital Partners. "Matt would've seen this problem in a heartbeat because it's what happened at LTCM."

JPMorgan, the nation's largest bank by assets, also announced that Mike Cavanagh, its former chief financial officer, will lead a firm-wide operating committee that will coordinate the bank's response to the loss.

-- CNNMoney's Maureen Farrell contributed to this report. 

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